People involved in the American Revolution
- John Adams, revolutionary, later President
- Samuel Adams, revolutionary
- Crispus Attucks, first casualty of the war
- John Glover (general), revolutionary general
- John Hancock
- James Otis
- Robert Treat Paine
- William Prescott
- Paul Revere, revolutionary
Public Office
- John Adams, 2nd U.S. president and 1st vice president
- John Quincy Adams, 6th U.S. president
- Joe Arpaio, Sheriff of Maricopa County in Arizona
- Michael Bloomberg, Mayor of New York City
- George Herbert Walker Bush, 41st U.S. president
- Andrew Card, State Rep., U.S. Secretary of Transportation, White House Chief of Staff
- Calvin Coolidge, mayor, state representative, senator and governor, 30th U.S. president
- Michael Dukakis, governor and 1988 Democratic nominee for president
- Richard Goodwin, speechwriter for Presidents John F. Kennedy and Lyndon B. Johnson and Senator Robert F. Kennedy; congressional investigator probing the 1950s Twenty One quiz show scandal
- John Hancock, Governor of Massachusetts and President of the Continental Congress
- Oliver Wendell Holmes, Jr., justice of the U.S. Supreme Court
- Edward Kennedy, U.S. Senator
- John F. Kennedy, 35th U.S. president
- Robert F. Kennedy, U.S. Attorney General and U.S. Senator (New York)
- John Forbes Kerry, U.S. Senator and 2004 Democratic nominee for president
- Tip O’Neill, 55th Speaker of the House, from 1977 -1987
- Frances Perkins, U.S. Secretary of Labor from 1933 – 1945 and first woman appointed to the U.S. Cabinet
- Mitt Romney, former governor
- Jane Swift, first and only female governor of Massachusetts
- John Volpe, U.S. Secretary of Transportation under President Nixon and Governor of Massachusetts
Science
- Ethan Allen, co-inventor of the single-action revolver
- Nima Arkani-Hamed, theoretical physicist
- Alexander Graham Bell, inventor
- Benjamin Franklin, scientist and public official
- Robert Goddard, inventor (“father of modern rocketry”)
- Elias Howe, inventor
- Melvin Johnson, prominent firearms designer
- Samuel Finley Breese Morse, inventor and artist
- William T.G. Morton, dentist and physician
- Albert Sacco, chemical engineer and Payload Specialist for NASA
- John Henry Schwarz, theoretical physicist
- Andrew Strominger, theoretical physicist
- Benjamin Thompson, physicist and inventor
- Edward Thorndike, psychologist
- Worcester Warner, mechanical engineer, astronomer
- Samuel Wellman, inventor of the crucible steel furnace
- Daniel Wesson, prominent firearms designer
- Eli Whitney, inventor
- Robert Wood, physicist, inventor